FRAX 597
FRAX597
CAS: 1286739-19-2
Molecular Formula: C29H28ClN7OS
FRAX 597 - Names and Identifiers
FRAX 597 - Physico-chemical Properties
| Molecular Formula | C29H28ClN7OS |
| Molar Mass | 558.1 |
| Melting Point | >220°C (dec.) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid |
| Color | Yellow |
| Storage Condition | Refrigerator |
| In vitro study | FRAX597 (100 n M) displays a significant inhibitory capacity toward YES1 (87%), RET (82%), CSF1R (91%), TEK (87%), PAK1 (82%), and PAK2 (93%), while displays minimal inhibitory activity towards the group II PAKs: PAK4 (0%), PAK6 (23%), and PAK7 (8%). FRAX597 treatment dramatically impairs the proliferation of Nf2-null SC4 Schwann cells (SC4 cells). FRAX597 displays an IC50 value of 48 nM against wild type PAK1, while IC 50 values against the V342F and V342Y PAK1 mutants are higher than 3μM and 2 μM, respectively. FRAX597 inhibits the proliferation and motility of both benign (Ben-Men1, 3μM) and malignant (KT21-MG1, 0.4 μM) meningiomas cells after treating of 72 h. |
| In vivo study | In NOD/SCID mice which bearing Nf2-/-SC4 Schwann cells, FRAX597 (100 mg/kg/day, p.o.) causes more significant tumor growth inhibition cpmpared with control mice. In SCID mice with orthotopic meningioma, FRAX597 (90 mg/kg/day, p.o.) significantly suppresses tumor growth. In KrasG12D mice, treatment with FRAX597 (90 mg/kg/day, p.o.) causes tumor regression and loss of Erk and Akt activity. |
FRAX 597 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.792 ml | 8.959 ml | 17.918 ml |
| 5 mM | 0.358 ml | 1.792 ml | 3.584 ml |
| 10 mM | 0.179 ml | 0.896 ml | 1.792 ml |
| 5 mM | 0.036 ml | 0.179 ml | 0.358 ml |
Last Update：2024-01-02 23:10:35
FRAX 597 - Reference Information
| biological activity | FRAX597 is a potent, ATP-competitive first-class inhibitor of PAKs for PAK1,PAK2, and PAK3 have an IC50 of 8 nM,13 nM, and 19 nM, respectively. |
| in vitro study | FRAX597 (100 n M) displays a significant inhibition capacity toward YES1 (87 %), RET (82 %), CSF1R (91 %), TEK (87 %), PAK1 (82 %), and PAK2 (93 %), while Events Management Index activity the group II: pakks (7 %), PAK6) (8%). FRAX597 treatment dramatically impairs the proliferation of Nf2-null SC4 Schwann cells (SC4 cells). FRAX597 displays an IC50 value of 48 nM against wild type PAK1, while IC 50 values against the V342F and V342Y PAK1 mutants are higher than 3μM and 2 μM, respectively. FRAX597 inhibits the proliferation and motility of both benign (Ben-Men1, 3μM) and malignant (KT21-MG1, 0.4 μM) meningiomas cells after treating of 72 h. |
| In vivo studies | In NOD/SCID mice which bearing Nf2-/-SC4 Schwann cells, FRAX 597 (100 mg/kg/day, p.o.) causes more significant tumor growth inhibition. In SCID mice with orthotopic meningioma, FRAX597 (90 mg/kg/day, p.o.) significantly suppresses tumor growth. In KrasG12D mice, treatment with FRAX597 (90 mg/kg/day, p.o.) causes tumor regression and loss of Erk and Akt activity. |
| Target | PAK1 8 nM (IC 50 ) PAK2 13 nM (IC 50 ) PAK3 19 nM (IC 50 ) |
Last Update：2024-04-09 21:11:58
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Tel: 609-228-6898
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tech@medchemexpress.com
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Product Name: FRAX597 Visit Supplier Webpage Request for quotation
CAS: 1286739-19-2
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CAS: 1286739-19-2
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View History
FRAX 597
Quinidine sulfate
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DICHLOROBIS(BENZONITRILE)PLATINUM (II)
C.I. 26370
6-BROMO-3-CHLORO INDAZOLE
POTASSIUM BICARBONATE
Big Gastrin I Human
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Quinidine sulfate
ate)L
DICHLOROBIS(BENZONITRILE)PLATINUM (II)
C.I. 26370
6-BROMO-3-CHLORO INDAZOLE
POTASSIUM BICARBONATE
Big Gastrin I Human
Germanic acid
TriMetazidine EP IMpurity-C